和玉兵
职　　称
  • 副研究员
电　　话
  • 010-82105921
电子邮件
  • heyubing@caas.cn
创新团队
  • 作物转基因及基因编辑技术与应用
研 究 组
  • 小麦基因编辑与新材料创制
研究中心
  • 作物遗传育种中心
研 究 生
  • 李文端
  • 孙欣荣
  • 宋倩琳
  • 钟玉楠
  • 彭丹
  • 李春芃
教育经历
  • 2010.09-2017.12，华中农业大学生命科学技术学院/作物遗传改良国家重点实验室，获博士学位；
  • 2006.09-2010.06，华中农业大学生命科学技术学院/国家生命科学理科基地班，获学士学位。
工作经历
  • 2023.02-今，中国农业科学院作物科学研究所，副研究员，博士生导师；
  • 2022.02-2023.02，中国农业科学院作物科学研究所，副研究员，中国农业科学院青年英才计划引进工程所级人才；
  • 2019.12-2022.02，南京农业大学作物遗传与种质创新国家重点实验室，副教授；
  • 2018.01-2019.12，华中农业大学作物遗传改良国家重点实验室，博士后。
研究方向
  • 基因组编辑技术开发与创新利用
荣誉称号
  • 2022年入选中国农业科学院青年英才计划引进工程所级人才
承担项目
  • 引导编辑介导的水稻定点长同源片段替换体系构建与应用，国家自然科学基金青年科学基金项目，主持，在研；
  • 引导编辑介导的水稻大片段精准基因替换和插入，中国农业科学院青年创新专项，主持，在研；
  • 利用功能模块组装开发新型精准基因组编辑器，中国农业科学院南繁专项，主持，在研。
主要论文
  • Zhu M, Yan L, Zhan Z, Chen H, Wang D, Xu M, Zheng Z, Zhang Y, Yang N, Wu J, Zhan H, Tian Y, Xiong L, He Y*. Transgene-Killer-CRISPR version 2 (TKC2) eliminates occasional transgene escape by coupling with a RUBY reporter. Plant Biotechnology Journal, 2025, DO1:10.1111/pbi.70257.下载
  • Mu Q, Yu G, Zhou G, He Y*, Zhang J*. DRBP-EDP: classification of DNA-binding proteins and RNA-binding proteins using ESM-2 and dual-path neural network. NAR Genomics and Bioinformatics, 2025, 7(2): lqaf058下载
  • Yang N#, Yan L#, Zheng Z, Zhang Y, Zhan H, Tian Y, Zhang T, Li R, Gong X, Xu M, Zhu M, Wu J, He Y*, Zhao Y. Editing gene families by CRISPR/Cas9: accelerating the isolation of multiple transgene-free null mutant combinations with much reduced labor-intensive analysis. Plant Biotechnology Journal, 2022, 20(2): 241-243.下载
more
  • LiuJL, Chen MM, Chen WQ, Liu CM, He Y†, Song XF†*. A CASE toolkit for easy and efficient multiplex transgene-free gene-editing. Plant Physiology, 2022, 188(4): 1843-1847.(† Senior author, * corresponding author)下载
  • He Y, Mudgett M, Zhao Y*. Advances in gene editing without residual transgenes in plants. Plant Physiology, 2022, 188(4): 1757-1768.下载
  • He Y*#, Zhang T#, Sun H, Zhan H, Zhao Y*. A reporter for noninvasively monitoring gene expression and plant transformation. Horticulture Research, 2020, 7: 152. (* corresponding author, # co-first author)下载
  • He Y, Zhu M, Wang L, Wu J, Wang Q, Wang R, Zhao Y*. Programmed Self-Elimination of the CRISPR/Cas9 Construct Greatly Accelerates the Isolation of Edited and Transgene-Free Rice Plants. Molecular Plant, 2018, 11(9): 1210-1213.下载
  • He Y, Yan L, Ge C, Yao XF, Han X, Wang R, Xiong L, Jiang L, Liu CM, Zhao Y*. PINOID Is Required for Formation of the Stigma and Style in Rice. Plant Physiology, 2019, 180(2): 926-936.下载
  • He Y, Zhu M, Wang L, Wu J, Wang Q, Wang R, Zhao Y*. Improvements of TKC Technology Accelerate Isolation of Transgene-Free CRISPR/Cas9-Edited Rice Plants. Rice Science, 2019, 26(2): 109-117.下载
  • He Y*#, Zhu M#, Wu J#, Ouyang L, Wang R, Sun H, Yan L, Wang L, Xu M, Zhan H, Zhao Y. Repurposing of anthocyanin biosynthesis for plant transformation and genome editing. Frontiers in Genome Editing, 2020, 2: 607982.下载
  • He Y, Zhao Y*. Technological breakthroughs in generating transgene-free and genetically stable CRISPR-edited plants. aBIOTECH, 2020, 1(1): 88-96.下载
  • He Y, Zhang T, Yang N, Xu M, Yan L, Wang L, Wang R, Zhao Y*. Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing. Journal of Genetics and Genomics, 2017, 44(9): 469-472.下载
  • He Y, Wang R, Dai X, Zhao Y*. On Improving CRISPR for Editing Plant Genes: Ribozyme-Mediated Guide RNA Production and Fluorescence-Based Technology for Isolating Transgene-Free Mutants Generated by CRISPR. Progress in Molecular Biology and Translational Science, 2017, 149: 151-166.下载
  • He Y, Zhao Y*. A key link between jasmonic acid signaling and auxin biosynthesis. Science China Life Sciences, 2015, 58(3): 311-312.下载
  • Wang Y, Wei S, He Y, Yan L, Wang R, Zhao Y*. Synergistic roles of LAX1 and FZP in the development of rice sterile lemma. The Crop Journal, 2020, 8(1): 16-25.下载
  • Li S, Li J, He Y, Xu M, Zhang J, Du W, Zhao Y*, Xia L*. Precise gene replacement in rice by RNA transcript-templated homologous recombination. Nature Biotechnology, 2019, 37(4): 445-450.下载
  • Sun Y, Zhang X, Wu C, He Y, Ma Y, Hou H, Guo X, Du W, Zhao Y*, Xia L*. Engineering Herbicide-Resistant Rice Plants through CRISPR/Cas9-Mediated Homologous Recombination of Acetolactate Synthase. Molecular Plant, 2016, 9(4): 628-631.下载
  • Chen J#, Li S#, He Y, Li J, Xia L*. An update on precision genome editing by homology-directed repair in plants. Plant Physiology, 2022, 188(4): 1780-1794.下载
  • Zhan H*#, Lu M#, Luo Q#, Tan F, Zhao Z, Liu M, He Y. OsCPD1 and OsCPD2 are functional brassinosteroid biosynthesis genes in rice. Plant Science, 2022, 325: 111482.下载
  • Zhang C#, Zhong X, Li S, Yan L, Li J, He Y, Lin Y, Zhang Y, Xia L*. Artificial evolution of OsEPSPS through an improved dual cytosine and adenine base editor generated a novel allele conferring rice glyphosate tolerance. Journal of Integrative Plant Biology, 2023, 65(9): 2194-2203.下载
  • Li J#, Zhang C#, He Y, Li S, Yan L, Li Y, Zhu Z, Xia L*. Plant base editing and prime editing: The current status and future perspectives. 2023, Journal of Integrative Plant Biology, 65(2): 444-467.下载
  • Li Y#, Li S#, Li C, Zhang C, Yan L, Li J, He Y, Guo Y, Lin Y, Zhang Y, Xia L*. Engineering a plant A-to-K base editor with improved performance by fusion with a transactivation module. Plant Communications, 2023, 4(6): 100667.下载
  • Liu M#, Lu M#, Zhao Z#, Luo Q, Liu F, Zhao J, He Y, Tian Y, Zhan H*. Rice ILI atypical bHLH transcription factors antagonize OsbHLH157/OsbHLH158 during brassinosteroid signaling. Plant Physiology, 2024, 194(3): 1545-1562.下载
  • Li Y#, Li S#, Li C, Zhang C, Yan L, Li J, He Y, Guo Y, Xia L*. Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants. aBIOTECH, 2024, 5(2): 127-139.下载
  • Yan L#, Tian J#, Li J, Li S, Zhang C, He Y, Xia L*. Analysis of a Series of Mutants Highlights Complex Regulation of Fusarium Head Blight Resistance Conferred by Fhb1 Locus in Wheat. Plant Biotechnology Journal, 2025, DOI:10.1111/pbi.70318.下载
  • Wang W#, Li S#, Yang J, Li J, Yan L, Zhang C, He Y, Xia L*. Exploiting the efficient Exo:Cas12i3-5M fusions for robust single and multiplex gene editing in rice. Journal of Integrative Plant Biology, 2025, 67(5): 1246-1253.下载
  • Wang W#, Yan L, Li J, Zhang C, He Y, Li S*, Xia L*. Engineering a robust Cas12i3 variant-mediated wheat genome editing system. Plant Biotechnology Journal, 2025, 23(3): 860-873.下载
授权专利
  • 一种快速高效获得非转基因的定向基因突变植株的方法和应用，授权专利号：ZL201810464473.5；
  • 一种植物基因组多位点编辑载体pCXUN-CAS9-RGR，授权专利号：ZL201710384742.2。

 

 

Copyright ©    中国农业科学院作物科学研究所版权所有 地址: 北京市海淀区中关村南大街12号    邮编: 100081    电话: 010-82109715    email：zksbgs@caas.cn ics.caas.cn , 京ICP备09069690号-3, 京公网安备 11010802014990号 技术支持：中国农业科学院农业信息研究所