曹双河
职　　称
  • 研究员
电　　话
  • 010-82108610
电子邮件
  • caoshuanghe@caas.cn
创新团队
  • 小麦品质研究与新品种选育
研 究 组
  • 小麦品质育种
研究中心
  • 作物遗传育种中心
研 究 生
  • 培养博士和硕士10余名，其中5人次获得国家奖学金，8人次获得企业奖学金，2人获得中国农科院和北京市优秀毕业生称号
教育经历
  • 1992年9月至1999年7月在河南农业大学攻读学士和硕士学位；1999年9月至2002年6月在中国农业大学攻读博士学位。
工作经历
  • 2002年7月至2007年7月在中国科学院遗传与发育生物学研究所任助理研究员；2007年8月至2008年1月在美国加州大学戴维斯分校做访问学者；2008年2月至2012年12月在俄克拉荷马州立大学和俄克拉荷马大学从事博士后研究；2013年1月至2014年5月在中国科学院遗传与发育研究所做客座；2014年6月在中国农业科学院作物科学研究所工作至今。
研究方向
  • 小麦分子遗传育种
荣誉称号
  • 2015年入选中国农业科学院“青年英才”
获奖成果
  • 获得神农中华农业科技奖一等奖两项（2017，2019）
承担项目
  • 主持国家自然科学基金面上项目（32472191）：小麦株高位点Rht26的图位克隆和调控机理解析 2025.1-2028.12
  • 参加生物育种专项（2023ZD0406903）：小麦优质新基因挖掘与育种价值评价（2023.12-2025.12）
  • 主持国家自然科学基金面上项目（32272182）：调控小麦Glu-1基因的转录因子鉴定和功能解析 2023.1-2026.12
  • 参加国家重点研发计划（2022YFF1002900）中的“水稻、小麦产量性状关键基因模块的演变规律及超高产分子设计”课题2022.1-2026.12
  • 参加国家自然科学基金集成项目（91935304）：小麦产量与品质性状关键基因的图位克隆和遗传网络解析 2020.1-2021.12
  • 主持中国农业科学院基本科研业务费专项（S2020YC02）：小麦FLC基因的功能解析2020.1-2020.12
  • 主持国家自然科学基金（31571663）：小麦高分子量麦谷蛋白亚基基因的转录调控解析2016.1-2019.12
  • 负责转基因生物新品种培育重大专项任务4（2016ZX08009003-4）：小麦和玉米品质基因克隆与功能验证2016.1-2020.12
  • 参加十三五重点研发项目（2016YFD0100500）：主要农作物品质性状形成的分子基础2016.1-2020.12
主要著作
  • Bian Y, Dong J, Li L, Xu D, Tian X, Dong Y, Zeng J, Cao Q, Dong Y, Xie L, Liu B, Qu K, Chao Y, Che R, Liu J, Zhang Y, Xia X, Sun D*, Lu F*, He Z*, Cao S*. Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits. Journal of Advanced Research, Available online 21 August 2025. https://doi.org/10.1016/j.jare.2025.08.025 (*Corresponding author)
  • Liu B, Sun M, Wang K, Bian Y, Che Y, Liu J, Luo X, Liu S, Xie L, Li L, Qu K, Chao Y, Che R, Ye X, Xia X, Mao L, He Z*, Li A*, Cao S*. Wheat domestication gene Q interplays with TaARF12 to antagonistically modulate plant architecture by integrating multiple hormone homeostasis. New Phytol. 2025 Aug 20. doi: 10.1111/nph.70487. (*Corresponding author)
  • Che R, Liu B, Chao Y, Bian Y, Xie L, Li L, Tian W, Xia X, He Z*, Cao S*. Deciphering genetic architecture and regulatory mechanism underlying the accumulation of seed storage proteins in wheat. J Exp Bot. 2025 Aug 6: eraf351. doi: 10.1093/jxb/eraf351. (*Corresponding author)
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  • Liu S, Xie L, Wu H, Xu D, Che R, Tian W, Liu B, Chao Y, Zhang Y, Xia n, He Z, Cao S* TaIAA10-6D orchestrates processing quality and grain yield by modulating glutenin/gliadin ratio and plant morphogenesis in wheat. The Crop Journal, Available online 3 July 2025. https://doi.org/10.1016/j.cj.2025.06.002 (*corresponding author)
  • Cao S*, Liu B, Wang D, Rasheed A, Xie L, Xia X, He Z*. (2024) Orchestrating seed storage protein and starch accumulation toward overcoming yield-quality trade-off in cereal crops. J Integr Plant Biol. 2024 Feb 26. 66: 468–483. doi: 10.1111/jipb.13633. (*Corresponding author)
  • Bian Y, Li L, Tian X, Xu D, Sun M, Li F, Xie L, Liu S, Liu B, Xia X, He Z, Cao S*. Rht12b, a widely used ancient allele of TaGA2oxA13, reduces plant height and enhances yield potential in wheat. Theor Appl Genet. 2023 Nov 21;136(12):253. doi: 10.1007/s00122-023-04502-y. (*Corresponding author)
  • Luo X, Liu B, Xie L, Wang K, Xu D, Tian X, Xie L, Li L, Ye X, He Z, Xia X, Yan L, Cao S*. The TaSOC1-TaVRN1 module integrates photoperiod and vernalization signals to regulate wheat flowering. Plant Biotechnol J. 2023 Nov 8. 22(3): 635-649. doi: 10.1111/pbi.14211. (*Corresponding author)
  • Li L, Xu D, Bian Y, Liu B, Zeng J, Xie L, Liu S, Tian X, Liu J, Xia X, He Z, Zhang Y, Zhang Y*, Cao S*. Fine mapping and characterization of a major QTL for plant height on chromosome 5A in wheat. Theor Appl Genet. 2023 Jul 4;136(7):167. doi: 10.1007/s00122-023-04416-9. (*Corresponding author)
  • Liu B, Li L, Fu C, Zhang Y, Bai B, Du J, Zeng J, Bian Y, Liu S, Song J, Luo X, Xie L, Sun M, Xu X, Xia X, Cao S*. Genetic dissection of grain morphology and yield components in a wheat line with defective grain filling. Theor Appl Genet. 2023 Jul 1;136(7):165. doi: 10.1007/s00122-023-04410-1. (*Corresponding author)
  • Xu D, Bian Y, Luo X, Jia C, Hao Q, Tian X, Cao Q, Chen W, Ma W, Ni Z, Fu X, He Z, Xia X, Cao S*. Dissecting pleiotropic functions of the wheat Green Revolution gene Rht-B1b in plant morphogenesis and yield formation. Development. 2023 Apr 11:dev.201601. doi: 10.1242/dev.201601 (*Corresponding author)
  • Xie L, Liu S, Zhang Y*, Tian W, Xu D, Li J, Luo X, Li L, Bian Y, Li F, Hao Y, He Z, Xia X, Song X*, Cao S*. Efficient proteome-wide identification of transcription factors targeting Glu-1: A case study for functional validation of TaB3-2A1 in wheat. Plant Biotechnol J. 2023 Jun 28. 21:1952-1965. doi: 10.1111/pbi.14103. (*Corresponding author)
  • Song J, Li L, Liu B, Dong Y, Dong Y, Li F, Liu S, Luo X, Sun M, Ni Z, Fei S, Xia X, Ni Z, He Z*, Cao S*. Fine mapping of reduced height locus RHT26 in common wheat. Theor Appl Genet. 2023 Mar 14;136(3):62. doi: 10.1007/s00122-023-04331-z (*Corresponding author)
  • Li L, Bian Y, Dong Y, Song J, Liu D, Zeng J, Wang F, Zhang Yong, He Z, Xia X, Zhang Yan*, Cao S*. Identification and validation of stable quantitative trait loci for yield component traits in wheat. The Crop Journal, 2022 11:558-563. https://doi.org/10.1016/j.cj.2022.09.012 (*Corresponding author)
  • Song J, Xu D, Dong Y, Li F, Bian Y, Li L, Luo X, Fei S, Li L, Zhao C, Zhang Y, Xia X, Ni Z, He Z*, Cao S*. Fine mapping and characterization of a major QTL for grain weight on wheat chromosome arm 5DL. Theor Appl Genet. 2022 Jul 29. 135:3237-3246. doi: 10.1007/s00122-022-04182-0. (*Corresponding author)
  • Liu S, Wang C, Gou J, Dong Y, Tian W, Fu L, Xiao Y, Luo X, He Z, Xia X, Cao S*. Genome-wide association study of ferulic acid content using 90K and 660K SNP chips in wheat. Journal of Cereal Science, July 2022, 106: 103498, https://doi.org/10.1016/j.jcs.2022.103498 (*Corresponding author)
  • Tian X, Xia X, Xu D, Liu Y, Xie L, Hassan MA, Song J, Li F, Wang D, Zhang Y, Hao Y, Li G, Chu C*, He Z*, Cao S*. Rht24b, an ancient variation of TaGA2ox-A9, reduces plant height without yield penalty in wheat. New Phytol. 2022 Jan; 233(2):738-750. doi: 10.1111/nph.17808 (*Corresponding author)
  • Cao S*, Luo X, Xu D, Tian X, Song J, Xia X, Chu C, He Z*. Genetic architecture underlying light and temperature mediated flowering in Arabidopsis, rice, and temperate cereals. New Phytol. 2021 Jun; 230(5):1731-1745. doi: 10.1111/nph.17276 (*Corresponding author)
  • Li J, Xie L, Tian X, Liu S, Xu D, Jin H, Song J, Dong Y, Zhao D, Li G, Li Y, Zhang Y, Zhang Y, Xia X, He Z*, Cao S*. TaNAC100 acts as an integrator of seed protein and starch synthesis exerting pleiotropic effects on agronomic traits in wheat. Plant J. 2021 Nov;108(3):829-840. doi: 10.1111/tpj.15485 (*Corresponding author)
  • Li L, Zhang Y, Zhang Y, Li M, Xu D, Tian X, Song J, Luo X, Xie L, Wang D, He Z, Xia X, Zhang Y*, Cao S*. Genome-Wide Linkage Mapping for Preharvest Sprouting Resistance in Wheat Using 15K Single-Nucleotide Polymorphism Arrays. Front Plant Sci. 2021 Oct 14; 12:749206. doi: 10.3389/fpls.2021.749206 (*Corresponding author)
  • Liu C, Song J, Liu S, Liu J, Xu D, Tian X, Bian Y, Dong Y, Wang F, Wang R, He Z, Xia X, Cao S*. Molecular mapping and characterization of QBp.caas-3BL for black point resistance in wheat (Triticum aestivum L.). Theor Appl Genet. 2021 Oct;134(10):3279-3286. doi: 10.1007/s00122-021-03893-0 (*Corresponding author)
  • Xie L, Zhang Y, Wang K, Luo X, Xu D, Tian X, Li L, Ye X, Xia X, Li W, Yan L, Cao S*. TaVrt2, an SVP-like gene, cooperates with TaVrn1 to regulate vernalization-induced flowering in wheat. New Phytol. 2021 May 231: 834–848. doi: 10.1111/nph.16339 (*Corresponding author)
  • Cao S*, Xu D, Hanif M, Xia X, He Z*. Genetic architecture underpinning yield component traits in wheat. Theor Appl Genet. 2020 Jun; 133(6):1811-1823. doi: 10.1007/s00122-020-03562-8 (*Corresponding author)
  • Cao S*, Luo X, Xie L, Gao C, Wang D, Holt BF 3rd, Lin H, Chu C, Xia X. The florigen interactor BdES43 represses flowering in the model temperate grass Brachypodium distachyon. Plant J. 2020 Apr; 102(2):262-275. doi: 10.1111/tpj.14622 (*Corresponding author)
  • Li J, Wang K, Li G, Li Y, Zhang Y, Liu Z, Ye X, Xia X, He Z*, Cao S*. Dissecting conserved cis-regulatory modules of Glu-1 promoters which confer the highly active endosperm-specific expression via stable wheat transformation. Crop Journal 2019 February 1 7(1): 8-18 (Featured cover article). https://doi.org/10.1016/j.cj.2018.08.003 (*Corresponding author)
  • Fu C, Du J, Tian X, He Z, Fu L, Wang Y, Xu D, Xu X, Xia X, Zhang Y*, Cao S*. Rapid identification and characterization of genetic loci for defective kernel in bread wheat. BMC Plant Biol. 2019 Nov 8; 19(1):483. doi: 10.1186/s12870-019-2102-6 (*Corresponding author)
  • Xu D, Wen W, Fu L, Li F, Li J, Xie L, Xia X, Ni Z, He Z*, Cao S*. Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat. Theor Appl Genet. 2019 Nov; 132(11):3191-3200. doi: 10.1007/s00122-019-03418-w (*Corresponding author)
  • Tian X, Zhu Z, Xie L, Xu D, Li J, Fu C, Chen X, Wang D, Xia X, He Z*, Cao S* (2019) Preliminary exploration for the source, spread and distribution of reduced height gene Rht24 in bread wheat. Crop Sci. 2019 January 1, 59(1): 19-24. https://doi.org/10.2135/cropsci2017.12.0711 (*Corresponding author)
  • Tian X, Wen W, Xie L, Fu L, Xu D, Fu C, Wang D, Chen X, Xia X, Chen Q, He Z*, Cao S*. Molecular mapping of reduced plant height gene Rht24 in bread wheat. Front Plant Sci. 2017 Aug 8; 8:1379. doi: 10.3389/fpls.2017.01379 (*Corresponding author)
  • Zhang P, He Z, Tian X, Gao F, Xu D, Liu J, Wen W, Fu L, Li G, Sui X, Xia, X， Wang C*, Cao S*. Cloning of TaTPP-6AL1 associated with grain weight in bread wheat and development of functional marker. Mol Breeding 37, 78 (2017) June 2. https://doi.org/10.1007/s11032-017-0676-y (*Corresponding author)
  • Wang J, Wen W, Hanif M, Xia X, Wang H, Liu S, Liu J, Yang L, Cao S*, He Z*. TaELF3-1DL, a homolog of ELF3, is associated with heading date in bread wheat. Mol Breeding 36, 161 (2016) Dec 08. https://doi.org/10.1007/s11032-016-0585-5 (*Corresponding author)
  • Hanif, M., Gao, F., Liu, J. Wen W, Zhang Y, Rasheed A, Xia X, He Z*, Cao S*. TaTGW6-A1, an ortholog of rice TGW6, is associated with grain weight and yield in bread wheat. Mol Breeding 36, 1 (2016) Dec 21. https://doi.org/10.1007/s11032-015-0425-z (*Corresponding author)
  • Cao S, Kumimoto RW, Gnesutta N, Calogero AM, Mantovani R, Holt BF 3rd*. A distal CCAAT/NUCLEAR FACTOR Y complex promotes chromatin looping at the FLOWERING LOCUS T promoter and regulates the timing of flowering in Arabidopsis. Plant Cell. 2014 Mar 7; 26(3):1009-17. doi: 10.1105/tpc.113.120352 (*Corresponding author)
  • Cao S, Li Z, Gong C, Xu H, Yang R, Hao S, Wang X, Wang D, Zhang X*. Identification and characterization of high-molecular-weight glutenin subunits from Agropyron intermedium. PLoS One. 2014 Feb 4; 9(2):e87477. doi: 10.1371/journal.pone.0087477 (*Corresponding author)
  • Cao S*, Yan L. Construction of a high-quality yeast two-hybrid (Y2H) library and its application in identification of interacting proteins with key vernalization regulator TaVRN-A1 in wheat. BMC Res Notes. 2013 Mar 5;6:81. doi: 10.1186/1756-0500-6-81 (*Corresponding author)
  • Cao S, Kumimoto RW, Siriwardana CL, Risinger JR, Holt BF 3rd*. Identification and characterization of NF-Y transcription factor families in the monocot model plant Brachypodium distachyon. PLoS One. 2011; 6(6):e21805. doi: 10.1371/journal.pone.0021805. (*Corresponding author)
  • Cao S, Siriwardana CL, Kumimoto RW, Holt BF 3rd*. Construction of high quality Gateway™ entry libraries and their application to yeast two-hybrid for the monocot model plant Brachypodium distachyon. BMC Biotechnol. 2011 May 19; 11:53. doi: 10.1186/1472-6750-11-53 (*Corresponding author)
  • Cao S, Carver BF, Zhu X, Fang T, Chen Y, Hunger RM, Yan L*. A single-nucleotide polymorphism that accounts for allelic variation in the Lr34 gene and leaf rust reaction in hard winter wheat. Theor Appl Genet. 2010 Mar 30; 121(2):385-392. doi: 10.1007/s00122-010-1317-6 (*Corresponding author)
  • Cao S, Xu H, Li Z, Wang X, Wang D, Zhang A, Jia X, Zhang X*. Identification and characterization of a novel Ag. intermedium HMW-GS gene from T. Aestivum-Ag. intermedium addition lines TAI-I series. Journal of Cereal Science, 45(3): 293-301 2007 May 1, https://doi.org/10.1016/j.jcs.2006.10.006 (*Corresponding author)
  • Cao S, Zhang X, Zhang A*. (2005) Review of the molecular regulation mechanism and genetics of photoperiod- and/or thermosensitive male sterility. Chinese Bulletin of Botany, 2005, 22(01): 19-26. (*Corresponding author)https://www.chinbullbotany.com/CN/Y2005/V22/I01/19
  • Cao S, Wan P, Zhang X*. (2004) Isolation and characterization of an Mla-like gene of wheat. Acta Botanica Sinica 46(6): 744-750. https://www.jipb.net/EN/Y2004/V46/I6/744 (*Corresponding author)
  • Cao S, Guo X, Liu D, Zhang X, Zhang A*. Preliminary gene-mapping of photoperiod-temperature sensitive genic male sterility in wheat (Triticum aestivum L.). Acta Genetica Sinica 31(3): 293-298. 2004 Mar; PMID: 15195570 (*Corresponding author)
授权专利
  • 曹双河、谢丽娜、张勇、夏先春、何中虎 。小麦储藏蛋白、淀粉和粒重调控基因TaB3-2A1的分子标记及特异性引物和应用。（CN 115772581 B）
  • 曹双河、刘炳炎、谢丽娜、车瑞、晁瑜恒、刘金栋、张勇、何中虎。 小麦ARF12-2B 调控产量的分子标记及其应用。(CN 120026127 B)
  • 何中虎、田秀苓、曹双河。用于鉴定小麦株高的分子标记以及特异引物。（ZL201610347796.7）
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  • 何中虎、田秀苓、曹双河。鉴定小麦株高表型的特异引物对及其应用。（ZL201810076340.0）

 

 

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